Latency of Sensations in Hyperalgesic Area

Hyperalgesic activity of kisspeptin in mice

BACKGROUND Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal cord, we examined the role of kisspeptin in the regulation of pain sensitivity in mice. RESULTS Immunofluorescent staining in the mouse skin sho...

Minimizing Metadata Access Latency in Wide Area Networked File Systems

Traditional network file systems, like NFS, do not extend to wide-area due to low bandwidth, high network latency, and dynamism introduced in the WAN environment. Metadata access latency is a significant performance problem for Wide Area File Systems, since metadata requests constitute a large portion of all file system requests, are synchronous, and cannot be cached at clients. We present Wire...

Cartesian Sensations

Descartes maintained that sensations of color and the like misrepresent the material world in normal circumstances. Some prominent scholars have argued that, to explain this Cartesian view, we must attribute to Descartes a causal account of sensory representation. I contend that neither the arguments motivating this reading nor the textual evidence offered in its support is sufficient to justif...

Pharmacologic Characteristics of a Medullary Hyperalgesic Center1

The effects of ethylketazocine, U-50,488, morphine and (-)nicotine administered both i.p. and into the mid-fourth ventricle of intact rats were investigated using a conventional high intensity tail-flick reflex and one evoked with a lower intensity thermal stimulus. The sensitivity of the low intensity thermally evoked tail avoidance reflex was several times that of a high intensity tailflick r...

Mechanics of Touch Sensations